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Mammillary bodies, and their projections to the anterior thalamus via the mammillothalamic tract, are important for recollective memory. [7] According to studies of rats with mammillary body lesions, damage to the medial mammillary nucleus lead to spatial memory deficits.
Some scientists have narrowed it down to specifically spatial and episodic memory. [9] [10] Damage to the mammillothalamic tract, ventral anterior nucleus, and ventral lateral nucleus can result in memory and language impairment. [11] Amnesia can be a result of disconnection of the mammillary bodies from the Papez circuit. [12]
The mammillothalamic tract is part of the Papez circuit (involved in spatial memory), starting and finishing in the hippocampus. [1] The fibers of the MMT are heavily myelinated. [2] [3] [4] It arises from the medial and lateral nuclei of the mammillary bodies, and from fibers that are directly continued from the fornix of the hippocampus.
Increasingly, however, researchers are wondering if there is a whole-body memory, that is, if different parts of our bodies can also make and store a type of memory, and if so, how these other ...
The anterior nuclei receive afferents from the hippocampus and subiculum directly via the fornix, and indirectly via the mammillary bodies and mammillothalamic tract (MTT). They send efferent fibers to the cingulate gyrus, limbic, and orbitofrontal cortex. [1] The anterior nuclei of the thalamus display functions pertaining to memory.
These new neurons contribute to pattern separation in spatial memory, increasing the firing in cell networks, and overall causing stronger memory formations. This is thought to integrate spatial and episodic memories with the limbic system via a feedback loop that provides emotional context of a particular sensory input.
People with the condition may also exhibit a dislike for sunlight and so may wish to stay indoors with the lights off. The mechanism of this degeneration is unknown, but it supports the current neurological theory that the mammillary bodies play a role in various "memory circuits" within the brain. An example of a memory circuit is the Papez ...
Fornix transection studies in macaques [1] have shown that the monkeys were strongly impaired on object-in-scene learning, which is a type of recall memory, specifically episodic-like memory (integrating what and where, although not when). Fornix transection in rodents impairs performance on tasks that require the encoding and retrieval of ...