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Activin A receptor, type I (ACVR1) is a protein which in humans is encoded by the ACVR1 gene; it is also known as ALK-2 (activin receptor-like kinase-2). [5] ACVR1 has been linked to the 2q23-24 region of the genome. [ 6 ]
There are three type I Activin receptors: ACVR1, ACVR1B, and ACVR1C. Each bind to a specific type II receptor-ligand complex. Despite the large amount of processes that these ligands regulate, they all operate through essentially the same pathway: A ligand binds to a Type two receptor, which recruits and trans-phosphorylate a type I
The activin A receptor also known as ACVR1C or ALK-7 is a protein that in humans is encoded by the ACVR1C gene. [5] ACVR1C is a type I receptor for the TGFB family of signaling molecules. [5] ACVR1C transduces signals of Nodal. Nodal binds to ACVR2B and then forms a complex with ACVR1C. These go on to recruit the R-SMADs SMAD2 or SMAD3. [6]
Activin receptor type-1B is a protein that in humans is encoded by the ACVR1B gene. [5] [6] ACVR1B or ALK-4 acts as a transducer of activin or activin-like ligands (e.g., inhibin) signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. These go on to recruit the R-SMADs SMAD2 or SMAD3. [7]
An Activin receptor is a receptor which binds activin. These proteins are receptor-type kinases of Ser/Thr type, which have a single transmembrane domain and a specific hydrophilic Cys-rich ligand-binding domain. [1] [2] [3] Types include: Activin type 1 receptors; Activin type 2 receptors
Activin β A and β B are identical to the two beta subunits of inhibin. A fifth subunit, activin β D, has been described in Xenopus laevis. Two activin β A subunits give rise to activin A, one β A, and one β B subunit gives rise to activin AB, and so on. Various, but not all theoretically possible, heterodimers have been described.
The activin type 2 receptors belong to a larger TGF-beta receptor family and modulate signals for transforming growth factor beta ligands. These receptors are involved in a host of physiological processes including, growth , cell differentiation , homeostasis , osteogenesis , apoptosis and many other functions.
11481 Ensembl ENSG00000114739 ENSMUSG00000061393 UniProt Q13705 P27040 RefSeq (mRNA) NM_001106 NM_007397 NM_001313757 RefSeq (protein) NP_001097 NP_001300686 NP_031423 Location (UCSC) Chr 3: 38.45 – 38.49 Mb Chr 9: 119.23 – 119.26 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Activin receptor type-2B is a protein that in humans is encoded by the ACVR2B gene. ACVR2B is an ...
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