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Fire in the Blood is a 2013 documentary film by Dylan Mohan Gray depicting what it claims is the intentional obstruction of access to low-cost antiretroviral drugs used in the treatment of HIV/AIDS to people in Africa and other parts of the global south, driven by multinational pharmaceutical companies holding patent monopolies and various Western governments (above all those of the United ...
Drug films are films that depict either illicit drug distribution or drug use, whether as a major theme, such as by centering the film around drug subculture or by depicting it in a few memorable scenes. Drug cinema ranges from gritty social realism depictions to the utterly surreal depictions in art film and experimental film.
The AUC (from zero to infinity) represents the total drug exposure across time. AUC is a useful metric when trying to determine whether two formulations of the same dose (for example a capsule and a tablet) result in equal amounts of tissue or plasma exposure. Another use is in the therapeutic drug monitoring of drugs with a narrow therapeutic ...
Using 2 drugs at the same time can sometimes affect each other's fraction unbound. For example, assume that Drug A and Drug B are both protein-bound drugs. If Drug A is given, it will bind to the plasma proteins in the blood. If Drug B is also given, it can displace Drug A from the protein, thereby increasing Drug A's fraction unbound.
All the Beauty and the Bloodshed is a 2022 American biographical documentary film about photographer, artist, and activist Nan Goldin.The film is produced, co-edited and directed by Laura Poitras, [3] and tackles Goldin's life through her advocacy during the HIV/AIDS crisis in the ‘80s, and her fight against the Sackler family for their role in the current opioid epidemic in the United ...
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Total drug exposure is most often estimated by area under the curve (AUC) methods, with the trapezoidal rule (numerical integration) the most common method. Due to the dependence on the length of x in the trapezoidal rule, the area estimation is highly dependent on the blood/plasma sampling schedule. That is, the closer time points are, the ...
This gives a = 100 μg/mL if the drug stays in the blood stream only, and thus its volume of distribution is the same as that is = 0.08 L/kg. If the drug distributes into all body water the volume of distribution would increase to approximately V D = {\displaystyle V_{D}=} 0.57 L/kg [ 8 ]