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Cannabinoid hyperemesis syndrome (CHS) is recurrent nausea, vomiting, and cramping abdominal pain that can occur due to prolonged, high-dose cannabis use. [ 4 ] [ 5 ] CHS is associated with frequent (weekly or more often), long-term (several months or longer) cannabis use; synthetic cannabinoids can also cause CHS.
Cannabis use disorder (CUD), also known as cannabis addiction or marijuana addiction, is a psychiatric disorder defined in the fifth revision of the Diagnostic and Statistical Manual of Mental Disorders and ICD-10 as the continued use of cannabis despite clinically significant impairment.
Cannabinoids are not mutagenic according to the Ames test. However, cannabis smoke has been found to be carcinogenic in rodents and mutagenic in the Ames test. Correlating cannabis use with the development of human cancers has been problematic due to difficulties in quantifying cannabis use, unmeasured confounders , and cannabinoids' potential ...
Inter-episodic phase (symptom free phase), is characterized as no discernible symptoms, normal everyday activities can occur, and this phase typically lasts one week to one month. The prodrome phase is known as the pre-emetic phase, characterized by the initial feeling of an approaching episode, still able to keep down oral medication .
Long-term cannabis users are at risk for developing cannabinoid hyperemesis syndrome (CHS), characterized by recurrent bouts of intense vomiting and abdominal cramping during or within 48 hours of heavy cannabis use. [112] The mechanism behind CHS is poorly understood and is contrary to the antiemetic properties of cannabis and cannabinoids.
Cannabinoid hyperemesis syndrome (similar to cyclic vomiting syndrome, but has cannabis use as its underlying cause). High doses of ionizing radiation sometimes trigger a vomit reflex. Violent fits of coughing, hiccups, or asthma; Anxiety; Depression; Overexertion (doing too much strenuous exercise can lead to vomiting shortly afterwards).
The patient was diagnosed with cannabinoid hyperemesis syndrome, linked to marijuana use. She tried to soothe the pain by showering and was burned.
Under the typical 50 ng/mL cutoff used for cannabis testing in the United States, an occasional or on-off user would be very unlikely to test positive beyond 3–4 days since the last use, and a chronic user would be likely to test positive much beyond 7 days all the way up to 90 days in a urine or hair sample.