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Subependymal giant cell astrocytoma (SEGA, SGCA, or SGCT) is a low-grade astrocytic brain tumor (astrocytoma) that arises within the ventricles of the brain. [1] It is most commonly associated with tuberous sclerosis complex (TSC). Although it is a low-grade tumor, its location can potentially obstruct the ventricles and lead to hydrocephalus.
Subependymal giant cell astrocytoma; Subependymoma; Consist of slow-growing astrocytomas, benign, and associated with long-term survival. Individuals with very slow-growing tumors where complete surgical removal by stereotactic surgery is possible may experience total remission. [6]
The best way to distinguish it from a subependymal giant cell astrocytoma is the size. [2] Diagnosis ... In 50-60% of cases, the tumor is in the fourth ventricle ...
9.1.2.2 Other low-grade B-cell lymphomas of the CNS 9.1.2.3 Anaplastic large cell lymphoma (ALK+/ALK−) 9.1.2.4 T-cell lymphomas and NK/T-cell lymphomas 9.2 Histiocytic tumors 9.2.1 Erdheim–Chester disease 9.2.2 Rosai–Dorfman disease 9.2.3 Juvenile xanthogranuloma 9.2.4 Langerhans cell histiocytosis 9.2.5 Histiocytic sarcoma
Cutaneous and visceral lesions may occur, including angiofibroma, cardiac rhabdomyomas, and renal angiomyolipomas. The central nervous system lesions seen in this disorder include hamartomas of the cortex, hamartomas of the ventricular walls, and subependymal giant cell tumors, which typically develop in the vicinity of the foramina of Monro.
The giant-cell glioblastoma is a histological variant of glioblastoma, presenting a prevalence of bizarre, multinucleated (more than 20 nuclei) giant (up to 400 μm diameter) cells. It occasionally shows an abundant stromal reticulin network and presents a high frequency of TP53 gene mutations .
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