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Many diseases cause sweat gland dysfunction: Acromegaly, a result of excess growth hormone, causes the size of sweat glands increase, which leads to thicker skin. [71] Aquagenic wrinkling of the palms, in which white papules develop on the palms after exposure to water, can sometimes come with abnormal aquaporin 5 in the sweat glands. [72]
Acquired idiopathic generalized anhidrosis appears to have a variety of etiologies. Theoretically, dysfunction or degeneration of cholinergic sympathetic nerve fibers involved in sweating (sudomotor neuropathy), dysfunction of acetylcholine receptors and/or cholinergic signals (idiopathic pure sudomotor failure may fall under this category), and primary failures of the sweat glands with ...
The amount of sweat glands varies across the human body, being highest in hand and foot regions (200–600 sweat glands per cm 2). [19] The response of the skin and muscle tissue to external and internal stimuli can cause the conductance to vary by several microsiemens. A correctly calibrated device can record and display the subtle changes. [21]
Intracutaneous injection of pilocarpine (sweat gland stimulant) is known to evoke no sweat response, indicating that lesions are on the post-synaptic side of the nerve-sweat gland junction. [1] The proposed pathomechanisms of idiopathic pure sudomotor failure include: A deficit within muscarinic cholinergic receptors of the eccrine sweat glands ...
In 2006, researchers uncovered that primary palmar hyperhidrosis, referring to excess sweating on the palms of the hands and feet, maps to the gene locus 14q11.2-q13. [ 4 ] Based on previous research using mice and rats, researchers looked towards the role of aquaporin 5 (AQP5), a water channel protein, in human individuals with primary focal ...
Eccrine sweat glands are found in virtually all skin, with the highest density in the palms of the hands, and soles of the feet, and on the head, but much less on the torso and the extremities. In other mammals, they are relatively sparse, being found mainly on hairless areas such as foot pads.
Sudomotor function refers to the autonomic nervous system control of sweat gland activity in response to various environmental and individual factors. Sweat production is a vital thermoregulatory mechanism used by the body to prevent heat-related illness as the evaporation of sweat is the body’s most effective method of heat reduction and the only cooling method available when the air ...
In instances where the cause is known, treatment should be directed at the primary pathology. In autoimmune diseases, such as Sjögren syndrome and systemic sclerosis, treatment of the underlying disease using immunosuppressive drugs may lead to improvement in hypohidrosis. In neurological diseases, the primary pathology is often irreversible.