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Three-dimensional schematic of the interstitium, a fluid-filled space supported by a network of collagen. In anatomy, the interstitium is a contiguous fluid-filled space existing between a structural barrier, such as a cell membrane or the skin, and internal structures, such as organs, including muscles and the circulatory system.
Interstitial cell refers to any cell that lies in the spaces between the functional cells of a tissue.. Examples include: Interstitial cell of Cajal (ICC); Leydig cells, cells present in the male testes responsible for the production of androgen (male sex hormone)
Extracellular fluid may be mechanically guided in this circulation by the vesicles between other structures. Collectively this forms the interstitium, which may be considered a newly identified biological structure in the body. [36] However, there is some debate over whether the interstitium is an organ. [37]
Scientists said in a study published Tuesday that they may have stumbled on an unknown organ that could significantly advance our understanding of cancer.
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Claude Bernard, French physician who introduced the concept of homeostasis. The human body and even its individual body fluids may be conceptually divided into various fluid compartments, which, although not literally anatomic compartments, do represent a real division in terms of how portions of the body's water, solutes, and suspended elements are segregated.
Interstitial cells of Cajal (ICC) are interstitial cells found in the gastrointestinal tract.There are different types of ICC with different functions. ICC and another type of interstitial cell, known as platelet-derived growth factor receptor alpha (PDGFRα) cells, are electrically coupled to smooth muscle cells via gap junctions, that work together as an SIP functional syncytium. [2]
Leydig cells release a class of hormones called androgens (19-carbon steroids). [8] They secrete testosterone, androstenedione and dehydroepiandrosterone (DHEA), when stimulated by the luteinizing hormone (LH), which is released from the anterior pituitary in response to gonadotropin releasing hormone which in turn is released by the hypothalamus.