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SARS-CoV-2 is the seventh known coronavirus to infect people, after 229E, NL63, OC43, HKU1, MERS-CoV, and the original SARS-CoV. [105] Like the SARS-related coronavirus implicated in the 2003 SARS outbreak, SARS‑CoV‑2 is a member of the subgenus Sarbecovirus (beta-CoV lineage B). [106] [107] Coronaviruses undergo frequent recombination. [108]
Distinct from the PANGOLIN tool, Pango lineages are regularly, manually curated based on the current globally circulating diversity. A large phylogenetic tree is constructed from an alignment containing publicly available SARS-CoV-2 genomes, and sub-clusters of sequences in this tree are manually examined and cross-referenced against epidemiological information to designate new lineages; these ...
Variants of severe acute respiratory syndrome coronavirus 2 are viruses that, while similar to the original, have genetic changes that are of enough significance to lead virologists to label them separately. SARS-CoV-2 is the virus that causes coronavirus disease 2019 (COVID-19).
In December 2019, a pneumonia outbreak was reported in Wuhan, China. [119] On 31 December 2019, the outbreak was traced to a novel strain of coronavirus, [120] which was given the interim name 2019-nCoV by the World Health Organization, [121] [122] [123] later renamed SARS-CoV-2 by the International Committee on Taxonomy of Viruses.
On 28 December 2019, Dr. Lili Ren, a virologist at the Peking Union Medical College in Beijing submitted a complete sequence of SARS-CoV-2 structure to GenBank. The sequence was never made public as it failed to include the annotations required for publication, and attempts by the NIH to contact Dr. Ren went unanswered.
Coronaviridae is a family of enveloped, positive-strand RNA viruses which infect amphibians, birds, and mammals.Commonly referred to as coronaviruses in the English language, the family coronaviridae includes the subfamilies Letovirinae and Orthocoronavirinae; the latter also known as coronavirinae.
Five years after the coronavirus began spreading around the world, it is still shaping how Americans live, work, eat and connect with neighbors. The virus was first flagged for international ...
Phylogenetic tree of SARS-CoV-2 and closely related betacoronaviruses (left) and their geographic context (right) Bats, along with their viruses, have large overlapping geographic ranges in Southeast Asia, [ 17 ] and there is a particularly great concentration and diversity of bat-related coronaviruses in Southern and Southwest China. [ 15 ]