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Lamotrigine has fewer drug interactions than many anticonvulsant drugs, although pharmacokinetic interactions with carbamazepine, phenytoin and other hepatic enzyme-inducing medications may shorten half-life. [84] Dose adjustments should be made on clinical response, but monitoring may be of benefit in assessing compliance. [5]
"Indiana University Department of Medicine Clinical Pharmacology Drug Interactions Flockhart Table ™". "INHIBITORS, INDUCERS AND SUBSTRATES OF CYTOCHROME P450 ISOZYMES". "The Life Raft Group: Long List of Inhibitors and Inducers of CYP3A4 and CYP2D6". "DRUGBANK Online: Cytochrome P-450 Enzyme Inhibitors".
When two drugs affect each other, it is a drug–drug interaction (DDI). The risk of a DDI increases with the number of drugs used. [1] A large share of elderly people regularly use five or more medications or supplements, with a significant risk of side-effects from drug–drug interactions. [2] Drug interactions can be of three kinds ...
Lamotrigine (Lamictal®) Lithium (Eskalith®, Lithobid®) Some studies show that the most effective treatment results from medication have been seen from combinations of mood stabilizers and ...
Lamictal (lamotrigine) – an anticonvulsant used as a mood stabilizer; Latuda – an atypical antipsychotic; Lexapro (escitalopram) – an antidepressant of the SSRI class; Librium (chlordiazepoxide) – a benzodiazepine used to treat acute alcohol withdrawal; Lithobid, Eskalith – a mood stabilizer
Alcohol is another substance that often cross-tolerates with other drugs. Findings of cross-tolerance with nicotine in animal models suggest that it is also possible in humans, and may explain why the two drugs are often used together. [6] Numerous studies have also suggested the possibility of cross-tolerance between alcohol and cannabis. [7]
Both newer and older drugs are generally equally effective in new onset epilepsy. [42] The newer drugs tend to have fewer side effects. [42] For newly diagnosed partial or mixed seizures, there is evidence for using gabapentin, lamotrigine, oxcarbazepine or topiramate as monotherapy. [42]
Humphreys noted that alcohol is, in essence, a drug, and people should take that into consideration when deciding how much to drink. “Take alcohol seriously as a drug with risks. Look honestly ...