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A reference range is usually defined as the set of values 95 percent of the normal population falls within (that is, 95% prediction interval). [2] It is determined by collecting data from vast numbers of laboratory tests. [citation needed]
C-reactive protein (CRP) is an annular (ring-shaped) pentameric protein found in blood plasma, whose circulating concentrations rise in response to inflammation. It is an acute-phase protein of hepatic origin that increases following interleukin-6 secretion by macrophages and T cells .
It is said that "normal concentration in healthy human serum is between 5 and 10 mg/L", but few lines before it is said that people with CRP concentration higher than 3.0 mg/L have a high risk of cardiovascular disease. If you connect these two sentences, you will get that "normal" is something that has "high risk".
C-reactive protein is found in between the beta and gamma zones producing beta/gamma fusion. IgA has the most anodal mobility and typically migrates in the region between the beta and gamma zones also causing a beta/gamma fusion in patients with cirrhosis, respiratory infection, skin disease, or rheumatoid arthritis (increased IgA).
In contrast, C-reactive protein (with a half-life of 6–8 hours) rises rapidly and can quickly return to within the normal range if treatment is employed. For example, in active systemic lupus erythematosus, one may find a raised ESR but normal C-reactive protein. [citation needed] They may also indicate liver failure. [11]
The normal laboratory value of serum total protein is around 7 g/dL. [ citation needed ] Scientists are able to identify blood proteins using Photo-affinity labeling, a means of using photo-reactive ligands as a labeling agent to identify targeted proteins.
Elevated levels are also associated with diabetes, hypertension, and cardiovascular disease; it was found that elevated levels are associated with elevated serum C-reactive protein (CRP), which could reflect an inflammatory and atherogenic milieu, possibly an alternative cause for elevated serum alkaline phosphatase. [10] Chronic kidney disease ...
C-reactive protein, an acute phase protein produced by the liver; cAMP receptor protein (catabolite gene activator protein) Cysteine-rich protein, a class of small proteins; Carbon-fiber-reinforced polymers; Chinese restaurant process, in probability theory; Chronic relapsing polyneuropathy, an acquired disorder of the nervous system