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  2. Rabeprazole - Wikipedia

    en.wikipedia.org/wiki/Rabeprazole

    Rabeprazole-ER was a 50 mg capsule composed of five non-identical 10 mg tablets that were designed to release rabeprazole at differing intervals throughout the gastrointestinal system. However, because two high quality clinical trials failed to demonstrate a benefit of rabeprazole-ER versus esomeprazole (another common PPI) for healing grade C ...

  3. Ilaprazole - Wikipedia

    en.wikipedia.org/wiki/Ilaprazole

    It is available in strengths of 5, 10, and 20 mg. Clinical studies show that ilaprazole is at least as potent a PPI as omeprazole when taken in equivalent doses. Studies also showed that ilaprazole significantly prevented the development of reflux oesophagitis .

  4. Proton-pump inhibitor - Wikipedia

    en.wikipedia.org/wiki/Proton-pump_inhibitor

    [20] [21] [22] In the United States, the Food and Drug Administration (FDA) has advised that over-the-counter PPIs, such as Prilosec OTC, should be used no more than three 14-day treatment courses over one year. [23] [24] Despite their extensive use, the quality of the evidence supporting their use in some of these conditions is variable.

  5. Discovery and development of proton pump inhibitors - Wikipedia

    en.wikipedia.org/wiki/Discovery_and_development...

    Rabeprazole binds to cysteine 813 and both 892 and 321. Lansoprazole reacts with cysteine 813 and cysteine 321, whereas pantoprazole and tenatoprazole react with cysteine 813 and 822. [ 18 ] [ 21 ] [ 22 ] [ 23 ] Reaction with cysteine 822 confers a rather special property to the covalently inhibited enzyme, namely irreversibility to reducing ...

  6. Domperidone - Wikipedia

    en.wikipedia.org/wiki/Domperidone

    Domperidone exposure increases proportionally with doses in the 10 to 20 mg dose range. [9] There is a 2- to 3-fold accumulation in levels of domperidone with frequent repeated oral administration of domperidone (four times per day (every 5 hours) for 4 days). [ 9 ]

  7. Donald L. Lucas - Pay Pals - The Huffington Post

    data.huffingtonpost.com/paypals/donald-l-lucas

    From January 2008 to December 2012, if you bought shares in companies when Donald L. Lucas joined the board, and sold them when he left, you would have a 47.8 percent return on your investment, compared to a -2.8 percent return from the S&P 500.