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Preload is related to the ventricular end-diastolic volume; a higher end-diastolic volume implies a higher preload. However, the relationship is not simple because of the restriction of the term preload to single myocytes. Preload can still be approximated by the inexpensive echocardiographic measurement end-diastolic volume or EDV.
Because greater EDVs cause greater distention of the ventricle, EDV is often used synonymously with preload, which refers to the length of the sarcomeres in cardiac muscle prior to contraction . An increase in EDV increases the preload on the heart and, through the Frank-Starling mechanism of the heart, increases the amount of blood ejected ...
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An increase in sympathetic stimulation to the heart increases contractility and heart rate. An increase in contractility tends to increase stroke volume and thus a secondary increase in preload. An increase in preload results in an increased force of contraction by Starling's law of the heart; this does not require a change in contractility.
Trend of central venous pressure as a consequence of variations in cardiac output. The three functions indicate the trend in physiological conditions (in the centre), in those of decreased preload (e.g. in hemorrhage, bottom curve) and in those of increased preload (e.g. following transfusion, top curve).
Preload (cardiology), maximum stretch of the heart at the end of diastole; preload (software), code-prefetching software for Linux; Preload (engineering), the internal application of stress to certain mechanical systems
Trend of central venous pressure as a consequence of variations in cardiac output. The three functions indicate the trend in physiological conditions (in the centre), in those of decreased preload (e.g. in hemorrhage, bottom curve) and in those of increased preload (e.g. following transfusion, top curve).
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