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The choice between the drugs is to a large degree determined by the characteristics of the patient being prescribed for, the drugs' side effects, and cost. Most drugs have other uses; sometimes the presence of other symptoms can warrant the use of one particular antihypertensive. Examples include: Age can affect the choice of medications.
Over the last 40 years, a variety of drugs have been developed from non-selective alpha-1 receptor antagonists to selective alpha-1 antagonists and alpha-1 receptor inverse agonists. [2] [3] The first drug that was used was a non-selective alpha blocker, named phenoxybenzamine and was used to treat BPH. [2]
Antihypertensive agents comprise multiple classes of compounds that are intended to manage hypertension (high blood pressure). Antihypertensive therapy aims to maintain a blood pressure goal of <140/90 mmHg in all patients, as well as to prevent the progression or recurrence of cardiovascular diseases (CVD) in hypertensive patients with established CVD. [2]
The antihypertensive characteristics of prazosin make it a second-line choice for the treatment of high blood pressure. [11] Prazosin is also useful in treating urinary hesitancy associated with benign prostatic hyperplasia, blocking α 1-adrenergic receptors, which control constriction of both the prostate and urethra. Although not a first ...
As with any drug, there are drug interactions that can occur with alpha blockers. For instance, alpha blockers that are used for the reduction of blood pressure, such as phenoxybenzamine or phentolamine can have synergy with other drugs that affect smooth muscle, blood vessels, or drugs used for erectile dysfunction (i.e. sildenafil, tamsulosin ...
The second group is the biphenyl-methyl group that binds to amino acids in both helices 6 and 7 (Phe 301, Phe 300, Trp 253 and His 256). The third one is the tetrazole group that interacts with amino acids in helices 4 and 5 ( Arg 167 and Lys 199 ).