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Serotonin syndrome (SS) is a group of symptoms that may occur with the use of certain serotonergic medications or drugs. [1] The symptoms can range from mild to severe, and are potentially fatal. [4] [5] [2] Symptoms in mild cases include high blood pressure and a fast heart rate; usually without a fever. [2]
Serotonin syndrome can be caused by taking multiple serotonergic drugs, such as SSRIs or SNRIs. Other drugs that contribute to serotonin syndrome include MAO inhibitors, linezolid, tedizolid, methylene blue, procarbazine, amphetamines, clomipramine, and more. [75] Early symptoms of serotonin syndrome may include nausea, vomiting, diarrhea ...
Serotonin syndrome is typically caused by the use of two or more serotonergic drugs, including SSRIs. [118] Serotonin syndrome is a condition that can range from mild (most common) to deadly. Mild symptoms may consist of increased heart rate, fever, shivering, sweating, dilated pupils, myoclonus (intermittent jerking or twitching), as well as ...
[2] [26] There may be a link between lower 5-hydroxytryptamine (5-HT, i.e. serotonin) receptor availability and symptoms of antidepressant discontinuation syndrome. [ 24 ] [ 27 ] Among antidepressants analyzed by Gastaldon et al. (2022), lofepramine , vortioxetine , mianserin , agomelatine , and esketamine are not associated with significantly ...
Symptoms are sometimes misinterpreted by doctors as symptoms of mental illness which can result in delayed treatment. [11] Symptoms may also be mistaken for similarly presenting conditions such as malignant hyperthermia, serotonin syndrome, or withdrawal from illicit drugs such as alcohol cocaine, or MDMA. [7]
About one in 10 people have restless leg syndrome, but the cause is a mystery. See what remedies doctors suggest. ... Antipsychotic drugs. Antidepressants that increase serotonin.
The intensity of the symptoms of serotonin syndrome vary over a wide spectrum, and the milder forms are seen even at nontoxic levels. [157] It is estimated that 14% of patients experiencing serotonin syndrome overdose on SSRIs; meanwhile the fatality rate is between 2% and 12%. [152] [158] [159]
[66] [67] Several case reports document serotonin syndrome induced by the combination of mirtazapine with other agents (olanzapine, [68] quetiapine, [69] tramadol and venlafaxine [70]). Adding fluvoxamine to treatment with mirtazapine may cause a significant increase in mirtazapine concentration. This interaction may necessitate an adjustment ...