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HPLC is widely used for manufacturing (e.g., during the production process of pharmaceutical and biological products), [4] [5] legal (e.g., detecting performance enhancement drugs in urine), [6] research (e.g., separating the components of a complex biological sample, or of similar synthetic chemicals from each other), and medical (e.g ...
Moreover, it is more specific than other serological methods for the diagnosis of some arbovirus. However, the test is relatively cumbersome and time intensive (taking a few days) relative to EIA kits that give quick results (usually several minutes to a few hours).
The use of trapezoidal rule in AUC calculation was known in literature by no later than 1975, in J.G. Wagner's Fundamentals of Clinical Pharmacokinetics. A 1977 article compares the "classical" trapezoidal method to a number of methods that take into account the typical shape of the concentration plot, caused by first-order kinetics. [8]
Summary of analytical methods for chiral analysis Method Brief narrative of principle and application; Chromatographic: Chiral HPLC Chiral HPLC is used to separate enantiomers either by direct or indirect separation mode. Widely employed to check enantiomeric purity, provided the reference standards of the racemate or the two enantiomers are ...
It distinguishes itself by being the only chromatographic method capable of presenting results as images and offers simplicity, cost-effectiveness, parallel analysis of samples, high sample capacity, rapid results, and the option for multiple detection methods. Le Roux's research team assessed HPTLC for determining salbutamol serum levels in ...
Nowadays, LC–MS has become one of the most widely used chemical analysis techniques because more than 85% of natural chemical compounds are polar and thermally labile and GC-MS cannot process these samples. [5] As an example, HPLC–MS is regarded as the leading analytical technique for proteomics and pharmaceutical laboratories.
The fundamental resolution equation is used in chromatography to help relate adjustable chromatographic parameters to resolution, and is as follows: . R s = [N 1/2 /4][(α-1)/α][k 2 '/(1+k 2 ')], where
In NMR spectroscopy, e.g. of the nuclei 1 H, 13 C and 29 Si, frequencies depend on the magnetic field, which is not the same across all experiments. Therefore, frequencies are reported as relative differences to tetramethylsilane (TMS), an internal standard that George Tiers proposed in 1958 and that the International Union of Pure and Applied Chemistry has since endorsed.