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Diphenhydramine, available in various salt forms, [74] such as citrate, [75] [76] hydrochloride, [77] and salicylate, [78] exhibits distinct molecular weights and pharmacokinetic properties. Specifically, diphenhydramine hydrochloride and diphenhydramine citrate possess molecular weights of 291.8 g/mol [ 79 ] and 447.5 g/mol , [ 80 ] respectively.
In the UK, Actavis marketed promethazine hydrochloride under the Sominex name. [41] It was available at least as early as 1985 as an OTC hypnotic. [42] Actavis also marketed a product by the name of Sominex Herbal, an herbal sleep aid with three natural active ingredients: hops, valerian, and passion flower extracts. [43]
NyQuil is also used as a sleep aid. [1] ... Doxylamine succinate (6.25 mg/15 mL) ... Diphenhydramine HCl 50 mg (antihistamine)
Benadryl Allergy is widely used as a sleep aid among adults. While it is not marketed as an over-the-counter (OTC) sleeping aid, most versions of Benadryl contain diphenhydramine, a drug with sedative properties. [6] Diphenhydramine (Benadryl) has also been used by parents to help improve their infant's sleep habits.
In sleep medicine, we use very small doses of melatonin multiple hours before bed to help gradually shift the body’s clock (circadian rhythm) in people with delayed sleep phase disorder, jet lag ...
The shorter elimination half-life of diphenhydramine (4–8 hours) compared to doxylamine may give it an advantage over doxylamine as a sleep aid in this regard. [ 27 ] Antihistamines like doxylamine are sedating initially but tolerance occurs with repeated use and can result in rebound insomnia upon discontinuation .