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Diphenhydramine, available in various salt forms, [73] such as citrate, [74] [75] hydrochloride, [76] and salicylate, [77] exhibits distinct molecular weights and pharmacokinetic properties. Specifically, diphenhydramine hydrochloride and diphenhydramine citrate possess molecular weights of 291.8 g/mol [ 78 ] and 447.5 g/mol , [ 79 ] respectively.
Benadryl Allergy is widely used as a sleep aid among adults. While it is not marketed as an over-the-counter (OTC) sleeping aid, most versions of Benadryl contain diphenhydramine, a drug with sedative properties. [6] Diphenhydramine (Benadryl) has also been used by parents to help improve their infant's sleep habits.
In the UK, Actavis marketed promethazine hydrochloride under the Sominex name. [41] It was available at least as early as 1985 as an OTC hypnotic. [42] Actavis also marketed a product by the name of Sominex Herbal, an herbal sleep aid with three natural active ingredients: hops, valerian, and passion flower extracts. [43]
NyQuil is also used as a sleep aid. [1] ... Doxylamine succinate (6.25 mg/15 mL) ... Diphenhydramine HCl 50 mg (antihistamine)
The shorter elimination half-life of diphenhydramine (4–8 hours) compared to doxylamine may give it an advantage over doxylamine as a sleep aid in this regard. [ 27 ] Antihistamines like doxylamine are sedating initially but tolerance occurs with repeated use and can result in rebound insomnia upon discontinuation .
Before adding any new supplement or sleep aid to your nighttime routine, speak with your healthcare provider to make sure it’s safe and appropriate for you. Meeko Media/Istockphoto 6.
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