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Supercritical fluids act as a new medium for the generation of novel crystalline forms of APIs (Active Pharmaceutical Ingredients) named as pharmaceutical cocrystals. Supercritical fluid technology offers a new platform that allows a single-step generation of particles that are difficult or even impossible to obtain by traditional techniques.
The supercritical solvent is passed into a vessel at lower pressure than the extraction vessel. The density, and hence dissolving power, of supercritical fluids varies sharply with pressure, and hence the solubility in the lower density CO 2 is much lower, and the material precipitates for collection. It is possible to fractionate the dissolved ...
Supercritical fluid chromatography (SFC) [1] is a form of normal phase chromatography that uses a supercritical fluid such as carbon dioxide as the mobile phase. [2] [3] It is used for the analysis and purification of low to moderate molecular weight, thermally labile molecules and can also be used for the separation of chiral compounds.
Supercritical carbon dioxide: Supercritical fluid chromatography, a form of liquid chromatography using supercritical carbon dioxide as the mobile phase; Supercritical water: Supercritical steam generator, a steam generator operating above the critical point of water, hence having no water–steam separation
Chematur's Super Critical Fluids technology was acquired by SCFI Group (Cork, Ireland) who are actively commercializing the Aqua Critox SCWO process for treatment of sludge, e.g. de-inking sludge and sewage sludge. Many long duration trials on these applications have been made and thanks to the high destruction efficiency of 99.9%+ the solid ...
Due to its high fluid density, sCO 2 enables compact and efficient turbomachinery. It can use simpler, single casing body designs while steam turbines require multiple turbine stages and associated casings, as well as additional inlet and outlet piping. The high density allows more compact, microchannel-based heat exchanger technology. [15]
Modern methods use supercritical fluids in the micronization process. These methods use supercritical fluids to induce a state of supersaturation, which leads to precipitation of individual particles. The most widely applied techniques of this category include the RESS process (Rapid Expansion of Supercritical Solutions), the SAS method ...
The SCWR operates at supercritical pressure. The reactor outlet coolant is supercritical water.Light water is used as a neutron moderator and coolant. Above the critical point, steam and liquid become the same density and are indistinguishable, eliminating the need for pressurizers and steam generators (), or jet/recirculation pumps, steam separators and dryers ().