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Pentachlorophenol (PCP) is an organochlorine compound used as a pesticide and a disinfectant. First produced in the 1930s, it is marketed under many trade names. [5] It can be found as pure PCP, or as the sodium salt of PCP, the latter of which dissolves easily in water. It can be biodegraded by some bacteria, including Sphingobium ...
[1] [4] PCP may cause hallucinations, distorted perceptions of sounds, and violent behavior. [4] [7] [8] As a recreational drug, it is typically smoked, but may be taken by mouth, snorted, or injected. [4] [5] [7] It may also be mixed with cannabis or tobacco. [1] [4] Adverse effects may include seizures, coma, addiction, and an increased risk ...
Olney's lesions, also known as NMDA receptor antagonist neurotoxicity (NAT), is a form of brain damage consisting of selective death of neurons but not glia, observed in restricted brain regions of rats and certain other animal models exposed to large quantities of psychoactive drugs that inhibit the normal operation of the neuronal NMDA receptor.
PCPr is an arylcyclohexylamine dissociative anesthetic drug with hallucinogenic and stimulant effects. It is around the same potency as phencyclidine, although slightly less potent than the ethyl homologue eticyclidine, [1] and has reportedly been sold as a designer drug in Germany and other European countries since the late 1990s.
4-Methyl-PCP, 4'-Methyl-PCP and 4''-Methyl-PCP (left to right) However, since the widespread sale of these compounds as grey-market designer drugs, nearly all such compounds that have come to prominence either have a bare cyclohexyl ring or a 2-ketocyclohexyl ring, while the piperidine is replaced by a variety of alkyl or cycloalkyl amines and ...
It is a weak NMDA receptor antagonist and is reported to produce dissociative and phencyclidine (PCP)-like effects in animals and humans at sufficiently high doses. [ 64 ] [ 65 ] [ 66 ] Even therapeutic doses have been found to produce mild dissociative-like effects in clinical studies. [ 64 ]
5. You’re Gaining Weight Unintentionally. While protein is often associated with weight loss, eating too much can have the opposite effect. “Consuming more protein than your body needs can ...
3-MeO-PCP binds to the NMDA receptor with higher affinity than PCP and has the highest affinity of the three isomeric anisyl-substitutions of PCP, followed by 2-MeO-PCP and 4-MeO-PCP. [2] [3] As of 2018, controlled clinical studies have not been performed in humans but the elimination half-life is estimated to be between 10 and 11 hours. [5]