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A mastocytoma or mast cell tumor is a type of round-cell tumor consisting of mast cells. It is found in humans and many animal species; it also can refer to an accumulation or nodule of mast cells that resembles a tumor.
A sarcoma is a tumor made of cells from connective tissue. Mast cell sarcoma is an extremely rare tumor. The largest analysis to date comprises 34 cases. [3] Prognosis is extremely poor. People with a mast cell sarcoma have no skin lesions, and pathology examination of the tumor shows it to be very malignant with an aggressive growth pattern. [4]
A mast cell (also known as a mastocyte or a labrocyte [1]) is a resident cell of connective tissue that contains many granules rich in histamine and heparin.Specifically, it is a type of granulocyte derived from the myeloid stem cell that is a part of the immune and neuroimmune systems.
The diagnosis of acute mast cell leukemia by the WHO criteria includes the requirement for a prevalence of 20% neoplastic mast cells in marrow and 10% in blood. [1] If the mast cells represent less than 10% of blood cells, the tumor is called "aleukemic" mast cell leukemia.
There are over 100 different known cancers that affect humans. [1] Cancers are often described by the body part that they originated in. However, some body parts contain multiple types of tissue, so for greater precision, cancers are additionally classified by the type of cell that the tumor cells originated from. These types include:
Mast cells seem to have other roles as well. Because they gather together around wounds, mast cells may play a part in wound healing. For example, the typical itching felt around a healing scab may be caused by histamine released by mast cells. Researchers also think mast cells may have a role in the growth of blood vessels (angiogenesis).