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Childhood-onset systemic lupus erythematosus (i.e., cSLE), also termed juvenile-onset systemic lupus erythematosus, juvenile systemic lupus erythematosus, and pediatric systemic lupus erythematosus, is a form of the chronic inflammatory and autoimmune disease, systemic lupus erythematosus (i.e., SLE), that develops in individuals up to 18 years old. [1]
The Checklist for Autism in Toddlers (CHAT) is a psychological questionnaire designed to evaluate risk for autism spectrum disorder in children ages 18–24 months. The 14-question test is filled out by the parent and a pediatrician or physician and takes approximately 5 minutes to complete. [ 1 ]
For diagnosis of NPSLE, it must be determined whether neuropsychiatric symptoms are indeed caused by SLE, whether they constitute a separate comorbid condition, or whether they are an adverse effect of disease treatment. In addition, onset of neuropsychiatric symptoms may happen prior to the diagnosis of lupus. [7]
If a child does not meet any of the following milestones, it "is an absolute indication to proceed with further evaluations. Delay in referral for such testing may delay early diagnosis and treatment and affect the [child's] long-term outcome." [22] No response to name (or gazing with direct eye contact) by 6 months. [27] No babbling by 12 months.
Common symptoms of SLE [11] SLE is one of several diseases known as "the great imitator" because it often mimics or is mistaken for other illnesses. [12] SLE is a classical item in differential diagnosis, [13] because SLE symptoms vary widely and come and go unpredictably. Diagnosis can thus be elusive, with some people having unexplained ...
[37] [38] The WHO estimates about 1 in 100 children had autism between 2012 and 2021, as that was the average estimate in studies during that period, with a trend of increasing prevalence over time. [b] [9] [10] This increasing prevalence has contributed to the myth perpetuated by anti-vaccine activists that autism is caused by vaccines. [39]