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Tamoxifen has been associated with a number of cases of hepatotoxicity. [55] Several different varieties of hepatotoxicity have been reported. [55] Tamoxifen can also precipitate non-alcoholic fatty liver disease in obese and overweight women (not in normal weight women) at an average rate of 40% after a year use with 20 mg/day. [56]
Menopause and sex lives at the intersection of women’s pain, pleasure, and aging, all topics that somehow still—in 2023—make doctors (and society at large) glitch, leaving women to suffer in ...
These fluctuations cause many of the physical changes during perimenopause as well as menopause, especially during the last 1–2 years of perimenopause (before menopause). [ 71 ] [ 75 ] Some of these changes are hot flashes , night sweats , difficulty sleeping, mood swings, vaginal dryness or atrophy , incontinence , osteoporosis , and heart ...
Few tamoxifen users have had increased rates of uterine cancer, hot flushes, and thromboembolisms. The drug can also cause hepatocarcinomas in rats. This is likely due to the ethyl group of the tamoxifen stilbene core that is subject to allylic oxidative activation causing DNA alkylation and strand scission.
From night sweats and vaginal dryness to sudden hormonal acne and Burning Mouth Syndrome (?!), menopause can usher in a whole host of symptoms, both well- and lesser-known. One that might fall ...
Genitourinary syndrome of menopause (GSM) was determined to be more accurate than vulvovaginal atrophy by two professional societies. [1] [19] [a] The term atrophic vaginitis does not reflect the related changes of the labia, clitoris, vestibule, urethra and bladder. [19] Overall, the current preferred term is Genitourinary syndrome of ...
Menopause belly is weight gain in the midsection due to hormonal changes. But MDs have advice for treating and preventing it in perimenopause and menopause.
[1] [2] Effects of menopause can include symptoms such as hot flashes, accelerated skin aging, vaginal dryness, decreased muscle mass, and complications such as osteoporosis (bone loss), sexual dysfunction, and vaginal atrophy. They are mostly caused by low levels of female sex hormones (e.g. estrogens) that occur during menopause. [1] [2]