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Signaling Gateway is a web portal dedicated to signaling pathways powered by the San Diego Supercomputer Center at the University of California, San Diego. It was initiated [1] by a collaboration between the Alliance for Cellular Signaling and Nature. A primary feature is the Molecule Pages database.
Complex multi-component signal transduction pathways provide opportunities for feedback, signal amplification, and interactions inside one cell between multiple signals and signaling pathways. [citation needed] A specific cellular response is the result of the transduced signal in the final stage of cell signaling.
The Pathway Interaction Database (PID) is a free biomedical database of human cellular signaling pathways. [1] The database contains information about the molecular interactions and reactions that take place in cells, with a particular focus on processes that might be relevant to cancer research and treatment.
mTOR signaling pathway. The PI3K/AKT/mTOR pathway is an intracellular signaling pathway important in regulating the cell cycle. Therefore, it is directly related to cellular quiescence, proliferation, cancer, and longevity. PI3K activation phosphorylates and activates AKT, localizing it in the plasma membrane. [1]
The ConsensusPathDB is a molecular functional interaction database, integrating information on protein interactions, genetic interactions signaling, metabolism, gene regulation, and drug-target interactions in humans. ConsensusPathDB currently (release 30) includes such interactions from 32 databases. [1]
SPIKE (Signaling Pathways Integrated Knowledge Engine) is a database of highly curated interactions for particular human pathways. [1] Development
NetPath [1] is a manually curated resource of human signal transduction pathways. It is a joint effort between Pandey Lab at the Johns Hopkins University and the Institute of Bioinformatics (IOB), Bangalore, India, [2] and is also worked on by other parties.
Examples of biological pathways in Reactome include signal transduction, innate and acquired immune function, transcriptional regulation, programmed cell death and classical intermediary metabolism. The pathways represented in Reactome are species-specific, with each pathway step supported by literature citations that contain an experimental ...