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  2. Synonymous substitution - Wikipedia

    en.wikipedia.org/wiki/Synonymous_substitution

    Protein translation involves a set of twenty amino acids.Each of these amino acids is coded for by a sequence of three DNA base pairs called a codon.Because there are 64 possible codons, but only 20-22 encoded amino acids (in nature) and a stop signal (i.e. up to three codons that do not code for any amino acid and are known as stop codons, indicating that translation should stop), some amino ...

  3. Single-nucleotide polymorphism - Wikipedia

    en.wikipedia.org/wiki/Single-nucleotide_polymorphism

    The upper DNA molecule differs from the lower DNA molecule at a single base-pair location (a G/A polymorphism) In genetics and bioinformatics, a single-nucleotide polymorphism (SNP / s n ɪ p /; plural SNPs / s n ɪ p s /) is a germline substitution of a single nucleotide at a specific position in the genome.

  4. Ka/Ks ratio - Wikipedia

    en.wikipedia.org/wiki/Ka/Ks_ratio

    This form of test can either identify sites that further laboratory research can examine to determine possible selective pressure; or, sites believed to have functional significance can be assigned into different K a /K s classes before the model is run.

  5. Genetic disorder - Wikipedia

    en.wikipedia.org/wiki/Genetic_disorder

    A genetic disorder is a health problem caused by one or more abnormalities in the genome.It can be caused by a mutation in a single gene (monogenic) or multiple genes (polygenic) or by a chromosome abnormality.

  6. Nucleotide base - Wikipedia

    en.wikipedia.org/wiki/Nucleotide_base

    DNA and RNA also contain other (non-primary) bases that have been modified after the nucleic acid chain has been formed. In DNA, the most common modified base is 5-methylcytosine (m 5 C). In RNA, there are many modified bases, including those contained in the nucleosides pseudouridine (Ψ), dihydrouridine (D), inosine (I), and 7-methylguanosine ...

  7. Evidence of common descent - Wikipedia

    en.wikipedia.org/wiki/Evidence_of_common_descent

    One of the strongest evidences for common descent comes from gene sequences. Comparative sequence analysis examines the relationship between the DNA sequences of different species, [1] producing several lines of evidence that confirm Darwin's original hypothesis of common descent.

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  9. Sequence homology - Wikipedia

    en.wikipedia.org/wiki/Sequence_homology

    Sequence homology is the biological homology between DNA, RNA, or protein sequences, defined in terms of shared ancestry in the evolutionary history of life. Two segments of DNA can have shared ancestry because of three phenomena: either a speciation event (orthologs), or a duplication event (paralogs), or else a horizontal (or lateral) gene ...