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An acute hemolytic transfusion reaction (AHTR), also called immediate hemolytic transfusion reaction, is a life-threatening reaction to receiving a blood transfusion. AHTRs occur within 24 hours of the transfusion and can be triggered by a few milliliters of blood. The reaction is triggered by host antibodies destroying donor red blood cells.
Febrile nonhemolytic reactions are, along with allergic transfusion reactions, the most common type of blood transfusion reaction and occur because of the release of inflammatory chemical signals released by white blood cells in stored donor blood [22] or attack on donor's white blood cells by recipient's antibodies. [36]
Platelet Transfusion: A Clinical Practice Guideline From the AABB Guideline from the American Association of Blood Banks published 2015. Australian Patient Blood Management Guidelines. Handbook of Transfusion Medicine Archived 2023-03-14 at the Wayback Machine Free book published in the UK 5th edition.
Febrile non-hemolytic transfusion reaction (FNHTR) is the most common type of transfusion reaction. It is a benign occurrence with symptoms that include fever but not directly related with hemolysis. [1] It is caused by cytokine release from leukocytes within the donor product as a consequence of white blood cell breakdown.
If a person without a Kidd blood antigen (for example a Jka-Jkb+ patient) receives a Kidd antigen (Jka-antigen for example) in a red blood cell transfusion and forms an alloantibody (anti-Jka); upon subsequent transfusion with Jka-antigen positive red blood cells, the patient may have a delayed hemolytic transfusion reaction as their anti-Jka antibody hemolyzes the transfused Jka-antigen ...
Within hospitals, transfusion committees are established to ensure safe hospital transfusion practice such as compliance with standards and guidelines, reviewing transfusion reactions and management of blood supply.
Washed red blood cells are red blood cells that have had most of the plasma, platelets and white blood cells removed and replaced with saline or another type of preservation solution. [ 1 ] [ 2 ] The most common reason for using washed red blood cells in transfusion medicine is to prevent the recurrence of severe allergic transfusion reactions ...
Transfusion hemosiderosis; Transfusion-associated circulatory overload; Transfusion-associated graft-versus-host disease; Transfusion-dependent anemia; Transfusion-related acute lung injury; Transfusion-related immunomodulation