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Amyloid-related imaging abnormalities (ARIA) are abnormal differences seen in magnetic resonance imaging of the brain in patients with Alzheimer's disease. ARIA is associated with anti-amyloid drugs, particularly human monoclonal antibodies such as aducanumab. [1] There are two types of ARIA: ARIA-E and ARIA-H.
Some plaques occur in the brain as a result of aging, but large numbers of plaques and neurofibrillary tangles are characteristic features of Alzheimer's disease. [5] The plaques are highly variable in shape and size; in tissue sections immunostained for Aβ, they comprise a log-normal size distribution curve, with an average plaque area of 400 ...
In vivo magnetic resonance spectroscopy (MRS) is a specialized technique associated with magnetic resonance imaging (MRI). [1] [2]Magnetic resonance spectroscopy (MRS), also known as nuclear magnetic resonance (NMR) spectroscopy, is a non-invasive, ionizing-radiation-free analytical technique that has been used to study metabolic changes in brain tumors, strokes, seizure disorders, Alzheimer's ...
In analysis of the fetal brain, MRI provides more information about gyration than ultrasound. [24] MRI is sensitive for the detection of brain abscess. [25] A number of different imaging modalities or sequences can be used with imaging the nervous system: T 1-weighted (T1W) images: Cerebrospinal fluid is dark.
PET is probably most useful in early cases of certain dementias (with classic examples being Alzheimer's disease and Pick's disease) where the early damage is too diffuse and makes too little difference in brain volume and gross structure to change CT and standard MRI images enough to be able to reliably differentiate it from the "normal" range ...
Figure 2: β-amyloid deposition. This image shows a Pittsburgh compound B (PIB)-PET scan of a patient with Alzheimer's disease on the left and an elderly person with normal memory on the right. Areas of red and yellow show high concentrations of PiB in the brain and suggest high amounts of amyloid deposits in these areas.
A normal brain on the left and a late-stage Alzheimer's brain on the right. During the final stage, known as the late-stage or severe stage, there is complete dependence on caregivers. [19] [33] [41] Language is reduced to simple phrases or even single words, eventually leading to complete loss of speech.
Functional magnetic resonance spectroscopy of the brain (fMRS) uses magnetic resonance imaging (MRI) to study brain metabolism during brain activation. The data generated by fMRS usually shows spectra of resonances, instead of a brain image, as with MRI. The area under peaks in the spectrum represents relative concentrations of metabolites.