Ads
related to: misoprostol parietal cell cancer treatmentcancer.osu.edu has been visited by 10K+ users in the past month
Search results
Results From The WOW.Com Content Network
Misoprostol is used for the prevention of NSAID-induced gastric ulcers.It acts upon gastric parietal cells, inhibiting the secretion of gastric acid by G-protein coupled receptor-mediated inhibition of adenylate cyclase, which leads to decreased intracellular cyclic AMP levels and decreased proton pump activity at the apical surface of the parietal cell.
Hyperplasia of parietal cells causes an abnormal release of HCl into the duodenum, which causes the ulcers of the duodenum. Excessive HCl production also causes hyperperistalsis, [ 14 ] a condition marked by excessive rapidity of the passage of food through the stomach and intestine and inhibits the activity of lipase , causing severe fatty ...
These drugs have emerged as the treatment of choice for acid-related diseases, including gastroesophageal reflux disease (GERD) and peptic ulcer disease. PPIs also can bind to other types of proton pumps such as those that occur in cancer cells and are finding applications in the reduction of cancer cell acid efflux and reduction of ...
The PPIs are given in an inactive form, which is neutrally charged and readily crosses cell membranes into intracellular compartments (like the parietal cell canaliculus) with acidic environments. In an acid environment, the inactive drug is protonated and rearranges into its active form.
Electrochemotherapy (ECT) is a relatively novel approach in the treatment of cancer, combining the use of electrical pulses with chemotherapy to enhance drug uptake by cancer cells. While predominantly used for the treatment of skin cancers and accessible tumors, its application in prostate cancer remains experimental and is under clinical ...
Multimodal treatments can often have synergistic effects leading to better clinical outcomes. [4] Diverse types of cancer can be treated via a multimodal approach, including non-small cell lung cancer [5] and gastric cancer. [6]
Ad
related to: misoprostol parietal cell cancer treatment