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Cushing's syndrome is a collection of signs and symptoms due to prolonged exposure to glucocorticoids such as cortisol. [4] [9] [10] Signs and symptoms may include high blood pressure, abdominal obesity but with thin arms and legs, reddish stretch marks, a round red face due to facial plethora, [11] a fat lump between the shoulders, weak muscles, weak bones, acne, and fragile skin that heals ...
Conversely, chronically elevated ACTH levels occur in primary adrenal insufficiency (e.g. Addison's disease) when adrenal gland production of cortisol is chronically deficient. In Cushing's disease, a pituitary tumor leads to excessive production of ACTH, which stimulates the adrenal cortex to produce high levels of cortisol.
The symptoms of Cushing's disease are similar to those seen in other causes of Cushing's syndrome. [5] Patients with Cushing's disease usually present with one or more signs and symptoms secondary to the presence of excess cortisol or ACTH. [6] Although uncommon, some patients with Cushing's disease have large pituitary tumors (macroadenomas).
Cushing syndrome can be tricky to diagnose since symptoms like weight gain and fatigue can be caused by a range of conditions. “Clinching a diagnosis of Cushing’s disease can be quite ...
Treatment for Cushing's syndrome aims to reduce the high levels of cortisol circulating through the human body. The course of action ultimately depends on the cause of the hypersecretion. Cushing's can be induced by repeated synthetic steroid use to treat inflammatory diseases, or it can also be caused by a tumor in the pituitary gland or ...
Fatigue, anorexia, weight loss, hypoglycemia, muscle weakness, nausea, vomiting, and hypotension. [1] Complications: Adrenal crisis [2] Causes: Autoimmune processes, congenital etiologies, and physical trauma. [3] Diagnostic method: Morning serum cortisol levels, [4] Insulin tolerance testing, and ACTH stimulation test [2] Differential diagnosis
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