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Haloperidol decanoate is provided in the form of 50 or 100 mg/mL oil solution of sesame oil and benzyl alcohol in ampoules or pre-filled syringes. [6] [7] [9] Its elimination half-life after multiple doses is 21 days. [10] [11] The medication is marketed in many countries throughout the world. [3] [12
As haloperidol is a high-potency typical antipsychotic, it tends to produce significant extrapyramidal side effects. According to a 2013 meta-analysis of the comparative efficacy and tolerability of 15 antipsychotic drugs it was the most prone of the 15 for causing extrapyramidal side effects.
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The most common typical antipsychotics associated with EPS are haloperidol and fluphenazine. [4] Atypical antipsychotics have lower D2 receptor affinity or higher serotonin 5-HT2A receptor affinity which lead to lower rates of EPS. [5] Other anti-dopaminergic drugs, like the antiemetic metoclopramide, can also result in extrapyramidal side ...
Side effects include restlessness and tardive dyskinesia. Amisulpride (Barhemsys), administered by intravenous injection. Domperidone (Motilium) Droperidol; Olanzapine (Zyprexa) Haloperidol (limited in usefulness by extra-pyramidal and sedative side-effects) Alizapride; Prochlorperazine (Compazine, Stemzine, Buccastem, Stemetil, Phenotil)
fluphenazine and haloperidol: more extrapyramidal side effects (EPS) and less antihistaminic effects (e.g. sedation), alpha adrenergic antagonism (e.g. orthostatic hypotension), and anticholinergic effects (e.g. dry mouth) middle: perphenazine and loxapine: intermediate D2 affinity, with more off-target effects than high-potency agents low ...
They also have essentially 100% bioavailability and can be used for drugs that are poorly absorbed or ineffective when they are given orally. [25] Some medications, such as certain antipsychotics, can be administered as long-acting intramuscular injections. [37] Ongoing IV infusions can be used to deliver continuous medication or fluids. [38]
Intravenous therapy (abbreviated as IV therapy) is a medical technique that administers fluids, medications and nutrients directly into a person's vein.The intravenous route of administration is commonly used for rehydration or to provide nutrients for those who cannot, or will not—due to reduced mental states or otherwise—consume food or water by mouth.