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Haloperidol decanoate is provided in the form of 50 or 100 mg/mL oil solution of sesame oil and benzyl alcohol in ampoules or pre-filled syringes. [6] [7] [9] Its elimination half-life after multiple doses is 21 days. [10] [11] The medication is marketed in many countries throughout the world. [3] [12
In Brazil, pharmacological torture involved the injection of alcohol into the tongue in the 1940s, the injection of ether into the scrotum in the 1960s, and drugs were used to cause strong contractions in the 1970s. Also, muscle relaxants were used to minimize muscular rigidity and bone fractures caused by electric shock in the 1970s. [4] [2]
Chemical restraint, such as forcible injection with the antipsychotic haloperidol or benzodiazepine sedative midazolam, may be used to sedate a patient who is agitated. [36]: 624 [37]: 152 In some countries, antipsychotics and sedatives can be forcibly administered to those who are committed, using intramuscular depot injection. [38]
Haloperidol is used in the treatment of schizophrenia, tics in Tourette syndrome, mania in bipolar disorder, delirium, agitation, acute psychosis, and hallucinations from alcohol withdrawal. [9] [10] [11] It may be used by mouth or injection into a muscle or a vein. [9] Haloperidol typically works within 30 to 60 minutes. [9]
Intrathecal administration is a route of administration for drugs via an injection into the spinal canal, or into the subarachnoid space so that it reaches the cerebrospinal fluid (CSF). It is useful in several applications, such as for spinal anesthesia, chemotherapy, or pain management. This route is also used to introduce drugs that fight ...
The most common typical antipsychotics associated with EPS are haloperidol and fluphenazine. [4] Atypical antipsychotics have lower D2 receptor affinity or higher serotonin 5-HT2A receptor affinity which lead to lower rates of EPS. [5] Other anti-dopaminergic drugs, like the antiemetic metoclopramide, can also result in extrapyramidal side ...