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In a confirmatory or primary screen with replicates, for the i-th test compound with replicates, we calculate the paired difference between the measured value (usually on the log scale) of the compound and the median value of a negative control in a plate, then obtain the mean ¯ and variance of the paired difference across replicates.
Comparison of the various grading methods in a normal distribution, including: standard deviations, cumulative percentages, percentile equivalents, z-scores, T-scores. In statistics, the standard score is the number of standard deviations by which the value of a raw score (i.e., an observed value or data point) is above or below the mean value of what is being observed or measured.
This is common on standardized tests. See also quantile normalization. Normalization by adding and/or multiplying by constants so values fall between 0 and 1. This is used for probability density functions, with applications in fields such as quantum mechanics in assigning probabilities to | ψ | 2.
This is the smallest value for which we care about observing a difference. Now, for (1) to reject H 0 with a probability of at least 1 − β when H a is true (i.e. a power of 1 − β), and (2) reject H 0 with probability α when H 0 is true, the following is necessary: If z α is the upper α percentage point of the standard normal ...
the value of T can be compared with its expected value under the null hypothesis of 50, and since the sample size is large, a normal distribution can be used as an approximation to the sampling distribution either for T or for the revised test statistic T−50.
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Standardization of the coefficient is usually done to answer the question of which of the independent variables have a greater effect on the dependent variable in a multiple regression analysis where the variables are measured in different units of measurement (for example, income measured in dollars and family size measured in number of individuals).
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