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Hexokinase deficiency is an extremely rare autosomal recessive condition that falls under the category of erythroenzymopathies, or defects in red cell enzymes. [2] Hexokinase deficiency manifests is associated with chronic nonspherocytic hemolytic anemia. [3] Hemolytic anemia seems to be the only clinical sign of hexokinase deficiency. [4]
Hexokinase I, also known as hexokinase A and HK1, is an enzyme that in humans is encoded by the HK1 gene on chromosome 10. Hexokinases phosphorylate glucose to produce glucose-6-phosphate (G6P), the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of ...
Asthma phenotyping and endotyping has emerged as a novel approach to asthma classification inspired by precision medicine which separates the clinical presentations of asthma, or asthma phenotypes, from their underlying causes, or asthma endotypes. The best-supported endotypic distinction is the type 2-high/type 2-low distinction.
Before iron deficiency anemia sets in, “the body will do everything it can to retain the right number of red blood cells. So, it will deplete the storage iron before it depletes the red blood ...
Red blood cells normally survive an average of about 120 days, becoming damaged (their oxygen-carrying capacity becomes compromised) as they age.
An asthma attack can also feel a little like a panic attack in some situations. “But asthma can also cause anxiety, so they can double up on each other,” says Dr. Mustafa.
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