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The crystal structure of CETP is that of dimer of two TUbular LIPid (TULIP) binding domains. [3] [4] Each domain consists of a core of 6 elements: 4 beta-sheets forming an extended superhelix; 2 flanking elements that tend to include some alpha helix. The sheets wrap around the helices to produce a cylinder 6 x 2.5 x 2.5 nm.
Higher concentrations of cholesteryl ester have been found in the caudate and putamen, but not the cerebellum, of people with Huntington disease compared with levels in controls. [4] Increase in cholesteryl ester has also been found in other neurological disorders like multiple sclerosis and Alzheimer's disease. [3]
A CETP inhibitor is a member of a class of drugs that inhibit cholesterylester transfer protein (CETP). [1] [2] ...
Nitrate esters, such as nitroglycerin, are known for their explosive properties, while polyesters are important plastics, with monomers linked by ester moieties. Esters of carboxylic acids usually have a sweet smell and are considered high-quality solvents for a broad array of plastics, plasticizers, resins, and lacquers. [2]
A plasma enzyme called lecithin-cholesterol acyltransferase (LCAT) converts the free cholesterol into cholesteryl ester (a more hydrophobic form of cholesterol), which is then sequestered into the core of the lipoprotein particle, eventually causing the newly synthesized HDL to assume a spherical shape.
Stretch wrap or stretch film, sometimes known as pallet wrap, is a highly stretchable plastic film that is wrapped around items. The elastic recovery keeps the items tightly bound. The elastic recovery keeps the items tightly bound.
acyl-CoA + cholesterol CoA + cholesterol ester Thus, the two substrates of this enzyme are acyl-CoA and cholesterol , whereas its two products are CoA and cholesteryl ester . This enzyme belongs to the family of transferases , specifically those acyltransferases transferring groups other than aminoacyl groups, the membrane-bound O ...
Evacetrapib was a drug under development by Eli Lilly and Company (investigational name LY2484595) that inhibits cholesterylester transfer protein (CETP inhibitor).CETP collects triglycerides from very low-density lipoproteins (VLDL) or low-density lipoproteins (LDL) and exchanges them for cholesteryl esters from high-density lipoproteins (HDL), and vice versa, but primarily increasing high ...