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Tetraethylammonium iodide is a quaternary ammonium compound with the chemical formula C 8 H 20 N + I −. It has been used as the source of tetraethylammonium ions in pharmacological and physiological studies, but is also used in organic chemical synthesis.
Writing in 1950, Graham made some observations on the toxic effects of tetraethylammonium bromide in humans. In one subject, described as a "healthy woman", 300 mg of tetraethylammonium bromide, i.v., produced incapacitating "curariform" (i.e., resembling the effects of tubocurarine) paralysis of the skeletal muscles, as well as marked drowsiness.
By comparison, tetraethylammonium and tetrapropylammonium ions were only absorbed to the extent of ~30%. [19] Distribution: Intraperitoneal administration of radio-labeled tetramethylammonium iodide to mice showed that TMA was rapidly distributed to all parts of the body, with the highest concentrations being in the kidney and liver. [7]
Quaternary ammonium cation. The R groups may be the same or different alkyl or aryl groups. Also, the R groups may be connected. In organic chemistry, quaternary ammonium cations, also known as quats, are positively-charged polyatomic ions of the structure [NR 4] +, where R is an alkyl group, an aryl group [1] or organyl group.
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