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There are two major mechanisms of NRTI resistance. The first being reduced incorporation of the nucleotide analog into DNA over the normal nucleotide. This results from mutations in the N-terminal polymerase domain of the reverse transcriptase that reduce the enzyme's affinity or ability to bind to the drug .
Many factors may contribute to depression in adults living with HIV, such as the effects of the virus on the brain, other infections or tumours, antiretroviral drugs and other medical treatment. [74] Rates of major depression are higher in people living with HIV compared to the general population, and this may negatively influence ...
Neuropsychiatric effects are the most common adverse effects, and include disturbed sleep (including nightmares, insomnia, disrupted sleep, and daytime fatigue), dizziness, headaches, vertigo, blurred vision, anxiety, and cognitive impairment (including fatigue, confusion, and memory and concentration problems), and depression, including suicidal thinking.
New RSV vaccines are now available to help prevent serious infection in people over 60. Doctors explain the RSV vaccine and its side effects in older adults.
It is taken by mouth as a tablet or solution and may be used in children over the age of three months. [5] [8] Abacavir is generally well tolerated. [8] Common side effects include vomiting, insomnia (trouble sleeping), fever, and feeling tired. [5]
There is no data available for stavudine use in HIV-infected adults aged 65 years or older. However, among 12,000 people over the age of 65, 30% developed peripheral neuropathy. [2] Additionally, since the elderly are more likely to have decreased renal function, they are more likely to develop toxic side effects. [11]
Image credits: chloekaaja Age gaps can lead to power imbalances in a relationship, Brook UK explains. “Age differences in relationships are common, though they are often more significant and ...
Amy Schumer once hopped on board the Ozempic trend, but the side effects were so intense she had to stop.. During a recent appearance on "The Howard Stern Show," the comedian, 43, opened up about ...