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First-generation antihistamines can easily cross the blood-brain barrier into the central nervous system to reach the H-1 receptors within, often causing drowsiness. [7] Second-generation antihistamines selectively bind to the peripheral H-1 receptors outside the blood-brain barrier, therefore they are less likely to cause sedation.
Other common adverse effects in first-generation H 1-antihistamines include dizziness, tinnitus, blurred vision, euphoria, incoordination, anxiety, increased appetite leading to weight gain, insomnia, tremor, nausea and vomiting, constipation, diarrhea, dry mouth, and dry cough.
[2] [4] Symptoms may include flushed skin, sweating, headache, itchiness, blurred vision, abdominal cramps and diarrhea. [2] [5] Onset of symptoms is typically 10 to 60 minutes after eating and can last for up to two days. [2] Rarely, breathing problems, difficulty swallowing, redness of the mouth, or an irregular heartbeat may occur. [2] [5]
Loratadine, sold under the brand name Claritin among others, is a medication used to treat allergies. [5] This includes allergic rhinitis (hay fever) and hives. [5] It is also available in drug combinations such as loratadine/pseudoephedrine, in which it is combined with pseudoephedrine, a nasal decongestant. [5]
Cinnarizine is an antihistamine and calcium channel blocker of the diphenylmethylpiperazine group. [5] It is prescribed for nausea and vomiting due to motion sickness [6] or other sources such as chemotherapy, [7] vertigo, [8] or Ménière's disease. [9] Cinnarizine is one of the leading causes of drug-induced parkinsonism. [5]
Emedastine (trade name Emadine) is a second generation antihistamine used in eye drops to alleviate the symptoms of allergic conjunctivitis. [1] It acts as a H 1 receptor antagonist. It works by blocking the action of histamine that causes allergic symptoms. It is used in form of the difumarate. [2]
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