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The age term is (140 – age). This means that a 20-year-old person (140 – 20 = 120) will have twice the creatinine clearance as an 80-year-old (140 – 80 = 60) for the same level of serum creatinine. The C-G equation assumes that a woman will have a 15% lower creatinine clearance than a man at the same level of serum creatinine.
The normal range of GFR, adjusted for body surface area, is 100–130 average 125 (mL/min)/(1.73 m 2) in men and 90–120 (mL/min)/(1.73 m 2) in women younger than the age of 40. In children, GFR measured by inulin clearance is 110 (mL/min)/(1.73 m 2 ) until 2 years of age in both sexes, and then it progressively decreases.
Males produce approximately 150 μmol to 200 μmol of creatinine per kilogram of body weight per 24 h, while females produce approximately 100 μmol/kg/24 h to 150 μmol/kg/24 h. In normal circumstances, all the creatinine produced is excreted in the urine. Creatinine concentration is checked during standard urine drug tests.
More specifically, optimal levels are generally close to a central tendency of the values found in the population. However, usual and optimal levels may differ substantially, most notably among vitamins and blood lipids, so these tables give limits on both standard and optimal (or target) ranges.
A creatinine of 0.7 mg/dL is normal for a small frail woman. A level of 2.0 mg/dL would indicate severe kidney disease in the old woman. The more muscle mass you have, and the more you use those muscles, the more more creatinine you should excrete. A frail old woman is expected to have very low creatinine levels.
Women make 70% to 80% less creatine than men do naturally and are also less likely on a whole to eat creatine-rich foods. Plus, ... it can raise creatinine levels, a waste product produced by ...
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