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It comprises the skin and its appendages, which act as a physical barrier between the external environment and the internal environment that it serves to protect and maintain the body of the animal. Mainly it is the body's outer skin. The integumentary system includes skin, hair, scales, feathers, hooves, claws, and nails.
Skin immunity is a property of skin that allows it to resist infections from pathogens. In addition to providing a passive physical barrier against infection, the skin also contains elements of the innate and adaptive immune systems which allows it to actively fight infections. Hence the skin provides defense in depth against infection.
The skin weighs an average of 4 kg (8.8 lb), covers an area of about 2 m 2 (22 sq ft), and is made of three distinct layers: the epidermis, dermis, and subcutaneous tissue. [1] The two main types of human skin are glabrous skin, the nonhairy skin on the palms and soles (also referred to as the "palmoplantar" surfaces), and hair-bearing skin. [16]
The skin barrier, or skin barrier function, is essentially the outermost layer of skin cells (the stratum corneum, if you’re fancy) plus the lipid matrix (composed of ceramides, cholesterols and ...
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A number of structural proteins (filaggrin, keratin), enzymes (e.g. proteases), lipids, and antimicrobial peptides contribute to maintain the important barrier function of the skin. Keratinization is part of the physical barrier formation (cornification), in which the keratinocytes produce more and more keratin and undergo terminal ...
The acid mantle is a very thin, delicate, slightly acidic film covering the entire surface of human skin, serving as a protective barrier against pathogens and reduces body odor. [ 1 ] [ 2 ] The acidic pH at the skin's surface mainly maintained by free amino acids and α-hydroxy acids ( lactic acids ) excreted from sweat ; free fatty acids and ...
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