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Positive-strand RNA viruses (+ssRNA viruses) are a group of related viruses that have positive-sense, single-stranded genomes made of ribonucleic acid. The positive-sense genome can act as messenger RNA (mRNA) and can be directly translated into viral proteins by the host cell's ribosomes.
Positive and negative sense RNA viruses are the two types of single-stranded RNA viruses classified based on the type of genome. Positive sense RNA is also known as plus-strand or sense strand while negative sense RNA is also known as minus-strand or antisense strand.
Positive-sense single-stranded RNA (+ssRNA) viruses are one such way and it is a key aspect of the infectious cycle of the virus. Two important examples of +ssRNA viruses are severe acute...
Viruses in the family Narnaviridae consist of a single molecule of non-encapsidated positive-strand RNA of 2.3-2.9 kb, which encodes a single protein of 80-104 kDa with amino acid sequence motifs characteristic of RdRps.
On the basis of genome type, single-stranded RNA viruses can be classified into positive and negative sense RNA viruses. The positive sense RNA virus is also referred to as sense strand or plus-strand, while on the other hand, negative sense RNA is also referred to as antisense or minus strand.
Coronaviruses (CoVs), enveloped positive-sense RNA viruses, are characterized by club-like spikes that project from their surface, an unusually large RNA genome, and a unique replication strategy.
Positive-sense single-stranded RNA (+ssRNA) viruses, the most abundant viruses of eukaryotes in nature, require the synthesis of negative-sense RNA (-RNA) using their genomic (positive-sense) RNA (+RNA) as a template for replication.
Single positive-strand or so-called ‘sense-strand RNA’ [ (+) ssRNA] viruses encompass many important pathogenic and nonpathogenic human, animal, and plant viruses, including poliovirus (PV), hepatitis C virus (HCV), rhinovirus, norovirus, Dengue virus, Zika virus, hoof and mouth disease virus, tobacco mosaic virus, and tomato bushy stunt virus (...
Hepatitis C is a positive sense, single-stranded RNA virus that replicates primarily, if not exclusively, within the hepatocytes of infected individuals. If left untreated, the virus can establish chronic infection, leading to complications such as hepatitis, cirrhosis, and hepatocellular carcinoma [2].
SARS-CoV-2 is an extremely contagious respiratory virus causing adult atypical pneumonia COVID-19 with severe acute respiratory syndrome (SARS). SARS-CoV-2 has a single-stranded, positive-sense RNA (+RNA) genome of ~ 29.9 kb and exhibits significant genetic shift from different isolates.