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Baclofen, sold under the brand name Lioresal among others, is a medication used to treat muscle spasticity, such as from a spinal cord injury or multiple sclerosis. [ 8 ] [ 9 ] It may also be used for hiccups and muscle spasms near the end of life, [ 9 ] and off-label to treat alcohol use disorder [ 10 ] [ 11 ] or opioid withdrawal symptoms. [ 12 ]
Often reserved for spastic cerebral palsy, baclofen can be administered through an intrathecal pump implanted just below the skin of the abdomen or behind the chest wall, with a catheter connected directly to the base of the spine. Intrathecal baclofen pumps sometimes carry serious clinical risks, such as infection or a possibly fatal sudden ...
Suvorexant is used for the treatment of insomnia, characterized by difficulties with sleep onset and/or sleep maintenance, in adults. [2] [6] At a dose of 15 to 20 mg and in terms of treatment–placebo difference, it reduces time to sleep onset by up to 10 minutes, reduces time awake after sleep onset by about 15 to 30 minutes, and increases total sleep time by about 10 to 20 minutes. [2]
Youssef commented that it is known that obesity affects lung function and does make obstructive lung disease such as COPD and asthma much more difficult to control, and so it is not yet clear if ...
While Kennedy was still running for president, before he dropped out to join President Trump's team, the HHS Secretary nominee campaigned on implementing "an extensive plan" to treat addiction.
The term "anticholinergic" is typically used to refer to antimuscarinics that competitively inhibit the binding of ACh to muscarinic acetylcholine receptors; such agents do not antagonize the binding at nicotinic acetylcholine receptors at the neuromuscular junction, although the term is sometimes used to refer to agents that do so. [3] [5]
“We want to keep them around—and this is a powerful way to say, ‘I really do love you, and you’re special to me.’” “If I were given the choice of choosing my family, I would still ...
The most striking discovery was the finding that baclofen (β-parachlorophenyl GABA), a clinically employed muscle relaxant [44] [45] mimicked, in a stereoselective manner, the effect of GABA. Later ligand-binding studies provided direct evidence of binding sites for baclofen on central neuronal membranes.