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Lymphocytosis is a feature of infection, particularly in children. In the elderly, lymphoproliferative disorders, including chronic lymphocytic leukemia and lymphomas, often present with lymphadenopathy and a lymphocytosis. [citation needed] Causes of absolute lymphocytosis include:
Duodenal lymphocytosis, sometimes called lymphocytic duodenitis, lymphocytic duodenosis, or duodenal intraepithelial lymphocytosis, is a condition where an increased number of intra-epithelial lymphocytes is seen in biopsies of the duodenal mucosa when these are examined microscopically.
A majority of reported cases in children are usually caused by infections or benign etiologies. In one study, 628 patients underwent a nodal biopsy and resulted benign or self-limited causes found in nearly 79% in patients younger than 30 years of age. This was also the case for nearly 59% of patients between the ages of 31-59 years old and 39% ...
Cutaneous lymphoid hyperplasia refers to a groups of benign cutaneous disorders characterized by collections of lymphocytes, macrophages, and dendritic cells in the skin. [ 2 ] : 725 Conditions included in this groups are: [ 2 ] : 725
Kawasaki disease (also known as mucocutaneous lymph node syndrome) is a syndrome of unknown cause that results in a fever and mainly affects children under 5 years of age. [6] It is a form of vasculitis , in which medium-sized blood vessels become inflamed throughout the body. [ 1 ]
It is a life-threatening disease of severe hyperinflammation caused by uncontrolled proliferation of benign lymphocytes and macrophages that secrete high amounts of inflammatory cytokines. It is classified as one of the cytokine storm syndromes. There are inherited and non-inherited (acquired) causes of HLH.
Pertussis toxin, formerly known as lymphocytosis-promoting factor, causes a decrease in the entry of lymphocytes into lymph nodes, which can lead to a condition known as lymphocytosis, with a complete lymphocyte count of over 4000/μl in adults or over 8000/μl in children. Besides targeting lymphocytes, it limits neutrophil migration to the lungs.
Children with common variable immunodeficiency (CVID) are also at a higher risk of developing a lymphoproliferative disorder. [ citation needed ] Some disorders that predispose a person to lymphoproliferative disorders are severe combined immunodeficiency (SCID), Chédiak–Higashi syndrome , Wiskott–Aldrich syndrome (an X-linked recessive ...