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Vitamin C megadosage is a term describing the consumption or injection of vitamin C (ascorbic acid) in doses well beyond the current United States Recommended Dietary Allowance of 90 milligrams per day, and often well beyond the tolerable upper intake level of 2,000 milligrams per day. [1]
In in vitro studies, the primary mechanism of high dosage intravenous ascorbic acid can be related to ascorbic acid's pro-oxidant activity, whereby hydrogen peroxide is formed. [ 17 ] [ 18 ] [ 19 ] In the extracellular fluid of cells, ascorbic acid dissociates into an ascorbate radical upon the reduction of transition metal ions, such as ferric ...
The US Recommended Dietary Allowance for vitamin C for adult women is 76 mg/day and for adult men 90 mg/day. Although Linus Pauling was known for highly respectable research in chemistry and biochemistry, he was also known for promoting the consumption of vitamin C in large doses. [25]
“Most people get adequate vitamin C through their diet. Taking a daily multivitamin can also provide a little additional vitamin C, often about 100 mg per supplement, so an additional high dose ...
Vitamin C and the Common Cold is a popular book by Linus Pauling, first published in 1970, on vitamin C, its interactions with common cold and the role of vitamin C megadosage in human health. [1] The book promoted the idea that taking large amounts of vitamin C could reduce the duration and severity of the common cold .
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