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The proportion of AST to ALT in hepatocytes is about 2.5:1, but because AST is removed from serum by the liver sinusoidal cells twice as quickly (serum half-life t 1/2 = 18 hr) compared to ALT (t 1/2 = 36 hr), so the resulting serum levels of AST and ALT are about equal in healthy individuals, resulting in a normal AST/ALT ratio around 1.
Muscle sources of the enzymes, such as intense exercise, are unrelated to liver function and can markedly increase AST and ALT. [5] Cirrhosis of the liver or fulminant liver failure secondary to hepatitis commonly reach values for both ALT and AST in the >1000 U/L range; however, many people with liver disease have normal transaminases.
This wide range of AST containing organs makes it a relatively less specific indicator of liver damage compared to ALT. An increase of mitochondrial AST in bloods is highly suggestive of tissue necrosis in myocardial infarction and chronic liver disease. More than 80% of the liver AST activity are contributed by mitochondrial form of the ...
Studies also show it can help reduce liver fat and improve liver enzymes. Consume at least three tablespoons a day of extra virgin olive oil in salads and sauces, or use it as a butter replacement ...
Olive Oil. One of the Mediterranean Diet's staple foods, olive oil, is worth highlighting for how it may support your liver health. “Olive oil is a good source of monounsaturated fat—a healthy ...
Additional Ways to Improve Liver Health. Dr. Kodali explains that fatty liver is one of the leading causes of liver disease, which is secondary to medical risk factors like high blood pressure, ...
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