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DES gained notoriety when it was shown to cause a rare vaginal tumor in girls and young women who had been exposed to this drug in utero.In 1971, the New England Journal of Medicine published a report showing that seven of eight girls and young women (ages 14 to 22) who had been diagnosed with vaginal clear cell adenocarcinoma had been exposed prenatally to DES. [5]
Common side effects include diarrhea and abdominal pain. [11] It is in pregnancy category X, meaning that it is known to result in negative outcomes for the fetus if taken during pregnancy. [11] In rare cases, uterine rupture may occur. [11] It is a prostaglandin analogue—specifically, a synthetic prostaglandin E 1 (PGE 1). [11]
Diethylstilbestrol (DES), also known as stilbestrol or stilboestrol, is a nonsteroidal estrogen medication, which is presently rarely used. [5] [6] [7] In the past, it was widely used for a variety of indications, including pregnancy support for those with a history of recurrent miscarriage, hormone therapy for menopausal symptoms and estrogen deficiency, treatment of prostate cancer and ...
Other adverse effects may include nausea, vomiting, fever, chills, diarrhea, headache, dizziness, warmth or hot flashes. [50] [43] [20] When used inside the vagina, misoprostol tends to have fewer gastrointestinal side effects. [6] Nonsteroidal anti-inflammatory medications such as ibuprofen reduce pain with medication abortion.
While misoprostol is 80 to 100% effective at terminating a pregnancy on its own, according to the Kaiser Family Foundation, taking both medications is more effective and has fewer side effects.
Other less common side effects included nausea, vomiting, diarrhea, dizziness, fatigue, and fever. [37] Pelvic inflammatory disease is a very rare but serious complication. [ 38 ] Excessive bleeding and incomplete termination of a pregnancy require further intervention by a doctor (such as a repeat dose of misoprostol or a vacuum aspiration ).
A recent large trial demonstrated that adding mifepristone to misoprostol for miscarriage treatment decreased treatment failure from 17.5% to 5.7%. It also decreased surgery rates from 14.6% to ...
Like other medications for the treatment of (ED), Cialis — and its generic version, tadalafil — can cause adverse effects at first. Fortunately, most tadalafil side effects are mild and ...