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Lumbar puncture helps identify leukemic cells in the cerebrospinal fluid (CSF). [3] Even if leukemic cells are not found in the CSF at the time of diagnosis, it is highly likely that they will spread there over time. Thus, prophylactic intrathecal chemotherapy, a treatment to lower the risk of leukemia spreading to the spinal cord and brain by ...
A lumbar puncture (also known as a spinal tap) can determine whether the spinal column and brain have been invaded. Brain and spinal column involvement can be diagnosed either through confirmation of leukemic cells in the lumbar puncture or through clinical signs of CNS leukemia as described above.
Illustration depicting lumbar puncture (spinal tap) Spinal needles used in lumbar puncture Illustration depicting common positions for lumbar puncture procedure. The person is usually placed on their side (left more commonly than right). The patient bends the neck so the chin is close to the chest, hunches the back, and brings knees toward the ...
[1] [4] Intravenous injection requires a direct injection of high-dose MTX into a patient’s vein; [4] Intrathecal injection, i.e. injection of the drug into the intrathecal space holding cerebrospinal fluid (CSF), is either administered via the Ommaya reservoir, an implanted container passing fluid into the brain, or by lumbar puncture. [1]
Bone marrow aspiration may also be performed on the tibial (shinbone) site in children up to 2 years of age while spinous process aspiration is frequently done in a lumbar puncture position and on the L3-L4 vertebrae. [citation needed] Anesthesia is used to reduce surface pain at the spot where the needle is inserted.
Generally, this staging should include positron emission tomography, computed tomography, or magnetic resonance imaging; lumbar puncture (i.e. spinal tap) with examination of the cerebral spinal fluid obtained from spinal taps for the presence of malignant B-cells; [2] and in cases where these tests are negative, bone marrow examination for the ...
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