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Oral ketoconazole has been used clinically as a steroidogenesis inhibitor in men, women, and children at dosages of 200 to 1,200 mg/day. [47] [48] [49] Numerous small studies have investigated the effects of oral ketoconazole on hormone levels in humans. [50]
An equianalgesic chart is a conversion chart that lists equivalent doses of analgesics (drugs used to relieve pain). Equianalgesic charts are used for calculation of an equivalent dose (a dose which would offer an equal amount of analgesia) between different analgesics. [1]
What Is Ketoconazole? Ketoconazole is an antifungal medication FDA-approved to treat several infections affecting the skin (including the scalp), like athlete’s foot or ringworm. Limited ...
Fluticasone propionate is broken down by CYP3A4 (cytochrome P450 3A4), and has been shown to interact with strong CYP3A4 inhibitors such as ritonavir and ketoconazole. [2] [3] Coadministration of ritonavir and fluticasone may lead to increased levels of fluticasone in the body, which may lead to Cushing's Syndrome and adrenal insufficiency. [22]
In July 2013, the European Medicines Agency's Committee on Medicinal Products for Human Use (CHMP) advised that oral medicines containing Ketoconazole should be suspended due to the high risk of hepatotoxicity outweighing its benefits. The advice does not affect topical ketoconazole products, and the oral use of the drug for Cushing's syndrome.
A 66-year-old paedophile who sexually abused two girls more than 30 years ago has been jailed for 22 years. Kevin Calderbank carried out the sexual assaults in Peterborough between 1985 and 1989.
Many children were among 30 people killed in a crowd crush at a church event in the southeastern city of Port Harcourt in 2022, according to police and security officials.
The first oral antimycotic imidazole, called ketoconazole, was available on the market in 1981. Triazole based drugs came shortly after and quickly gained popularity due to its broader spectrum of antifungal activity and less toxicity. [20] Terconazole was the first triazole-based antifungal drug synthesized for human use.