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The use of docetaxel during chemotherapy, especially when given weekly, may lead to complications with the lacrimal drainage system. The mechanism for this problem seems to be secretion of docetaxel by the lacrimal gland which can then cause stenosis, or narrowing, of the punctum and canalicular outflow system. [ 27 ]
Dose limit – higher doses cause high toxicity and long-term use lead to cumulative neurotoxicity and hematopoietic toxicity. [12] Neuropathy which is significant side effect can develop at any time in therapy and require an interruption of treatment.
Hyperammonaemia, thrombocytopenia, polycystic ovaries, SIADH (uncommon), hepatic failure (rare), pancreatitis (rare), leucopenia (rare), neutropenia (rare), pure red cell aplasia (rare), agranulocytosis (rare), extrapyramidal syndrome (rare), reduced BMD with long-term use, pleural effusion (rare) and multiorgan hypersensitivity reaction (rare).
James, Nicholas D; Sydes, Matthew R; Clarke, Noel W; et al. (19 March 2016), "Addition of docetaxel, zoledronic acid, or both to first-line long-term hormone therapy in prostate cancer (STAMPEDE): survival results from an adaptive, multiarm, multistage, platform randomised controlled trial", The Lancet, 387 (10024): 1163– 77, doi:10.1016 ...
In fact, long-term use of Ozempic may reduce the risk of major adverse cardiovascular events like heart attack in people with type 2 diabetes. stefanamer / iStock. 6. Thyroid Cancer.
Studies on Long-Term Semaglutide Use. More studies are needed, but long-term semaglutide use appears to be safe. A 2022 study — funded by Novo Nordisk, the manufacturer of Ozempic and Wegovy ...
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