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Potential Risks of GLP-1 Agonists. Although GLP-1 medications can be highly effective, they are not without some risks. Due to slowed gastric emptying, common side effects may include nausea ...
Danuglipron is a small-molecule GLP-1 agonist developed by Pfizer [1] that, in an oral formulation, is under investigation as a therapy for diabetes mellitus. Initial results from a randomized controlled trial indicate that it reduced weight [2] and improved diabetic control. The most commonly reported adverse events were nausea, diarrhea, and ...
Like any drug, GLP-1 agonists have potential side effects. The most common GLP-1 side effects are gastrointestinal, like nausea, vomiting, diarrhea, indigestion, abdominal pain and constipation.
Pfizer announced on Dec. 1 that it was discontinuing phase 3 clinical trials of the twice-daily version due to high rates of adverse side effects. While these were mostly mild, a large percentage ...
GLP-1 agonists were initially developed for type 2 diabetes. [5] The 2022 American Diabetes Association (ADA) standards of medical care in diabetes include GLP-1 agonists or SGLT2 inhibitors as a first-line pharmacological therapy for type 2 diabetes in patients who have or are at high risk for atherosclerotic cardiovascular disease or heart failure.
The most common side effects are nausea, diarrhea, vomiting, abdominal pain, and decreased appetite. [8] It is a glucagon-like peptide-1 receptor agonist (GLP-1 agonist) consisting of GLP-1(7-37) covalently linked to an Fc fragment of human IgG4. GLP-1 is a hormone
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