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Pentachlorophenol (PCP) is an organochlorine compound used as a pesticide and a disinfectant. First produced in the 1930s, it is marketed under many trade names. [5] It can be found as pure PCP, or as the sodium salt of PCP, the latter of which dissolves easily in water. It can be biodegraded by some bacteria, including Sphingobium ...
PCP is self-administered and induces ΔFosB expression in the D1-type medium spiny neurons of the nucleus accumbens, [3] [26] and accordingly, excessive PCP use is known to cause addiction. [3] PCP's rewarding and reinforcing effects are at least partly mediated by blocking the NMDA receptors in the glutamatergic inputs to D1-type medium spiny ...
PCPr is an arylcyclohexylamine dissociative anesthetic drug with hallucinogenic and stimulant effects. It is around the same potency as phencyclidine, although slightly less potent than the ethyl homologue eticyclidine, [1] and has reportedly been sold as a designer drug in Germany and other European countries since the late 1990s.
In 2008, concentrations as high as 35 ng/m 3, 10 times higher than the EPA guideline limit of 3.4 ng/m 3, have been documented inside some houses in the U.S. [31] Volatilization of PCBs in soil was thought to be the primary source of PCBs in the atmosphere, but research suggests ventilation of PCB-contaminated indoor air from buildings is the ...
Some are carcinogens per IARC, possibly including breast cancer. [1] Many POPs are capable of endocrine disruption within the reproductive system, the central nervous system, or the immune system. [26] People and animals are exposed to POPs mostly through their diet, occupationally, or while growing in the womb. [1]
Phencyclidine (PCP) is believed to be the first arylcyclohexylamine with recognized anesthetic properties, but several arylcyclohexylamines were described before PCP in the scientific literature, beginning with PCA (1-phenylcyclohexan-1-amine) the synthesis of which was first published in 1907. PCP itself was discovered in 1926 but not ...
3-MeO-PCMo is a dissociative anesthetic drug which is similar in structure to phencyclidine [1] [2] and been sold online as a designer drug. [3] [4] The inhibitory effect of 3-MeO-PCMo on the reduction in the density of the drebrin clusters by NMDAR stimulation with glutamic acid is lower than that of PCP or 3-MeO-PCP, with half maximal inhibitory concentration (IC 50) values of 26.67 μM (3 ...
The effects of 3-MeO-PCP in humans were not described until 1999 when a chemist using the pseudonym John Q. Beagle wrote that 3-MeO-PCP was qualitatively similar to PCP with comparable potency. [1] Interest in gray-market dissociates accelerated in 2008, when an online research chemical vendor began offering the less potent 4-MeO-PCP . [ 1 ]