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Carbon dioxide content in fresh air (averaged between sea-level and 10 kPa level, i.e., about 30 km (19 mi) altitude) varies between 0.036% (360 ppm) and 0.041% (412 ppm), depending on the location. [46] In humans, exposure to CO 2 at concentrations greater than 5% causes the development of hypercapnia and respiratory acidosis. [47]